#KnowBrainer #Resources

SBE Prophylaxis Guidlelines

https://www.heart.org/-/media/data-import/downloadables/pe-pdf-chd-infectiveendocarditiswalletcard-ucm_307644.pdf

 

https://www.heart.org/en/health-topics/infective-endocarditis

 

Pre-Procedure Antibiotic Use

All doses shown below are administered once as a single dose 30-60 min before the procedure.

Standard general prophylaxis

  • Amoxicillin
  • Adult dose: 2 g PO
  • Pediatric dose: 50 mg/kg PO; not to exceed 2 g/dose

Unable to take oral medication

  • Ampicillin
  • Adult dose: 2 g IV/IM
  • Pediatric dose: 50 mg/kg IV/IM; not to exceed 2 g/dose

Allergic to penicillin

  • Clindamycin
  • Adult dose: 600 mg PO
  • Pediatric dose: 20 mg/kg PO; not to exceed 600 mg/dose

Allergic to penicillin

  • Cephalexin or other first- or second-generation oral cephalosporin in equivalent dose (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)
  • Adult dose: 2 g PO
  • Pediatric dose: 50 mg/kg PO; not to exceed 2 g/dose
  • Azithromycin or clarithromycin
  • Adult dose: 500 mg PO
  • Pediatric dose: 15 mg/kg PO; not to exceed 500 mg/dose

Allergic to penicillin and unable to take oral medication

  • Clindamycin
  • Adult dose: 600 mg IV
  • Pediatric dose: 20 mg/kg IV; not to exceed 600 mg/dose
  • Cefazolin or ceftriaxone (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)
  • Adult dose: 1 g IV/IM
  • Pediatric dose: 50 mg/kg IV/IM; not to exceed 1 g/dose

References: 

Medscape, Antibiotic Prophylactic Regimens for Endocarditis- AMA guidelines, updated May 14, 2013

Wright,T,et al: Antibiotic Prophylaxis in Dermatologic Surgery Advisory Statement 2008 JAAD 59:3;464-473,2008

https://www.ncbi.nlm.nih.gov/pubmed/20000873