#KnowBrainer #Resources
SBE Prophylaxis Guidlelines
https://www.heart.org/en/health-topics/infective-endocarditis
Pre-Procedure Antibiotic Use
All doses shown below are administered once as a single dose 30-60 min before the procedure.
Standard general prophylaxis
- Amoxicillin
- Adult dose: 2 g PO
- Pediatric dose: 50 mg/kg PO; not to exceed 2 g/dose
Unable to take oral medication
- Ampicillin
- Adult dose: 2 g IV/IM
- Pediatric dose: 50 mg/kg IV/IM; not to exceed 2 g/dose
Allergic to penicillin
- Clindamycin
- Adult dose: 600 mg PO
- Pediatric dose: 20 mg/kg PO; not to exceed 600 mg/dose
Allergic to penicillin
- Cephalexin or other first- or second-generation oral cephalosporin in equivalent dose (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)
- Adult dose: 2 g PO
- Pediatric dose: 50 mg/kg PO; not to exceed 2 g/dose
- Azithromycin or clarithromycin
- Adult dose: 500 mg PO
- Pediatric dose: 15 mg/kg PO; not to exceed 500 mg/dose
Allergic to penicillin and unable to take oral medication
- Clindamycin
- Adult dose: 600 mg IV
- Pediatric dose: 20 mg/kg IV; not to exceed 600 mg/dose
- Cefazolin or ceftriaxone (do not use cephalosporins in patients with a history of immediate-type hypersensitivity penicillin allergy, such as urticaria, angioedema, anaphylaxis)
- Adult dose: 1 g IV/IM
- Pediatric dose: 50 mg/kg IV/IM; not to exceed 1 g/dose
References:
Medscape, Antibiotic Prophylactic Regimens for Endocarditis- AMA guidelines, updated May 14, 2013
Wright,T,et al: Antibiotic Prophylaxis in Dermatologic Surgery Advisory Statement 2008 JAAD 59:3;464-473,2008
https://www.ncbi.nlm.nih.gov/pubmed/20000873